Drivers are being advised that the A19 will be closed between 8pm and 6am to allow for essential resurfacing works to take place.
Drivers wishing to travel southbound will be diverted via A684 Osmotherley Interchange southbound exit slip road, A684 to Northallerton, A168, A19/A61 South Kilvington Interchange entry slip road to re-join the A19 southbound.
Kyle Maylard, Highways Agency project manager, said:
This resurfacing work has been planned overnight to minimise disruption and to take place when traffic flows are at their lowest. Drivers are asked to plan their journeys and to follow the signed diversions.
Members of the public should contact the Highways Agency Information Line on 0300 123 5000.
Journalists should contact the Highways Agency press office on 0844 693 1448 and use the menu to speak to the most appropriate press officer.