The Highways England scheme will see a 3 mile section of the A160 between the A180 and the Port of Immingham upgraded to a dual carriageway along its entire length.
Improvements will also be made to junctions along the route, including a new roundabout at the junction with the A180, a new bridge over the A160 on Town Street, and a new road under the railway line by the port.
There will be an overnight closure of the A160 Humber Road between Manby Road roundabout and Rosper Road from 8pm on Saturday 17 October to 10am on Sunday 18 October to install phone cables.
The eastbound exit slip road on the A180 at Brocklesby interchange will also be closed from 8pm on Thursday 29 October until 6am on Friday 30 October to install safety barriers.
There will be a full weekend closure of the A160 between Ulceby Road and Brocklesby interchange from 8pm on Friday 30 October until 6am Monday 2 November to carry out drainage work.
Drivers will be able to follow clearly signed diversion routes when the roads are closed.
Highways England project manager Ben Ridgeon said:
We are carrying out this improvement work at night and at weekends when traffic levels are at their lowest to minimise disruption to road users.
Once this scheme has been completed, congestion will be reduced, journey times will become more reliable, and safety will be improved for road users and the local community. There will also be better access to the Port of Immingham and the surrounding area.
The project began in March and aims to provide better access to the port and the surrounding area, stimulating growth and unlocking economic benefits. It is due to be completed in summer 2016.
The Port of Immingham is the UK’s largest port by tonnage and handles up to 55 million tonnes of goods every year, including nearly 20 million tonnes of oil and 10 million tonnes of coal.
More details on the scheme, including a computer-generated video showing how the upgraded road will look, are available on the scheme page.
Members of the public should contact the Highways England customer contact centre on 0300 123 5000.
Journalists should contact the Highways England press office on 0844 693 1448 and use the menu to speak to the most appropriate press officer.