Highways England is replacing the bridge joints on both sides of the carriageway between Derwenthaugh (junction 73) and Scotswood (junction 74).
Over the last few weeks work has been taking place on the southbound carriageway and temporary road plates have been in place to allow traffic to run over the bridge during the day.
This weekend the A1 southbound will be closed from 8pm on Saturday 25 March until 6am on Monday 27 March to allow the temporary road plates to be removed and the road to be fully reopened to traffic following completion of the joint replacement.
Work will then move to the northbound carriageway and will continue to be carried out overnight between 8pm and 6am and the existing temporary speed limit of 50mph will remain in place.
Highways England project manager Michael Hoult said:
It is essential that we carry out this maintenance work on the bridge joints at Blaydon Haugh Viaduct.
We will be carrying out the work overnight when traffic levels are at their lowest to keep disruption for drivers to a minimum.
The temporary road plates which have been installed over the expansion joint will be removed over the weekend and the speed limit will return to normal. Work will then start straight away on the northbound carriageway.
The northbound carriageway will be closed, seven days a week (8pm-6am) until the bridge joint has been replaced. This work is dependent on reasonable weather conditions and is expected to be completed next month.
Clearly signed diversions will be in place during the closures.
Members of the public should contact the Highways England customer contact centre on 0300 123 5000.
Journalists should contact the Highways England press office on 0844 693 1448 and use the menu to speak to the most appropriate press officer.