The cellular localization of avian influenza virus PB1-F2 protein alters the magnitude of IFN2 promoter

And NFκB-dependent promoter antagonism in chicken cells.

From:
Foreign, Commonwealth & Development Office
Published
23 January 2019
Country:
Pakistan, Vietnam
Document Type:
Journal Article
Theme:
Agriculture
Authors:
James, J, Smith, N, Ross, C, Iqbal, M

Abstract

The accessory protein, PB1-F2, of influenza A virus (IAV) functions in a chicken host to prolong infectious virus shedding and thus the transmission window. Here we show that this delay in virus clearance by PB1-F2 in chickens is accompanied by reduced transcript levels of type 1 interferon (IFN)-induced genes and NFκB-activated pro-inflammation cytokines.

This is a publication arising from the Zoonoses and Emerging Livestock Systems (ZELS) programme

Citation

James J, Smith N, Ross C, Iqbal M, Goodbourn S, Digard P, Barclay W, Shelton H (2019). The cellular localization of avian influenza virus PB1-F2 protein alters the magnitude of IFN2 promoter and NFκB-dependent promoter antagonism in chicken cells. J Gen Virol. 100(3):414-430.

The cellular localization of avian influenza virus PB1-F2 protein alters the magnitude of IFN2 promoter and NFκB-dependent promoter antagonism in chicken cells

Published 23 January 2019
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