Decreased protein C function predicts mortality in patients with cirrhosis
Protein C (PrC) regulates inflammation and cell death and has known predictive/therapeutic roles in sepsis
Abstract
Protein C (PrC), a physiological anticoagulant, regulates inflammation and cell death and has known predictive/therapeutic roles in sepsis. Accumulating evidences suggest plasma hypercoagulability results in progression of fibrosis and formation of microclots causing end‐organ dysfunction. We investigated a possible association between natural anticoagulants—PrC, protein S (PrS) and antithrombin III (AT)—and clinical outcomes in cirrhotics.
This research was supported by the UK Department for International Development’s Operational Research Capacity Building Programme led by the International Union Against TB and Lung Disease (The Union)
Citation
Patil AG, Bihari C, Shewade HD, Nigam N, Sarin SK. Decreased protein C function predicts mortality in patients with cirrhosis. Int. J. Lab. Hematol. [Internet]. 2018; Available from: https://onlinelibrary.wiley.com/doi/abs/10.1111/ijlh.12836
Links
Decreased protein C function predicts mortality in patients with cirrhosis