Contribution of segment 3 to the acquisition of virulence in contemporary H9N2 avian influenza viruses.
This study investigates the molecular basis for this increased virulence, comparing a virus from the 1990s and a contemporary field strain
Abstract
H9N2 avian influenza viruses (AIVs) circulate in poultry throughout much of Asia, the Middle East, and Africa. These viruses cause huge economic damage to poultry production systems and pose a zoonotic threat both in their own right and in the generation of novel zoonotic viruses, for example, H7N9. In recent years, it has been observed that H9N2 viruses have further adapted to gallinaceous poultry, becoming more highly transmissible and causing higher morbidity and mortality. Here, we investigate the molecular basis for this increased virulence, comparing a virus from the 1990s and a contemporary field strain
This is a publication arising from the Zoonoses and Emerging Livestock Systems (ZELS) programme.
Citation
Clements A, Sealy J, Peacock T, Sadeyen J, Hussain S, Lycett S, Shelton H, Digard P, Iqbal M (2020). Contribution of segment 3 to the acquisition of virulence in contemporary H9N2 avian influenza viruses. J Virol. 94:e01173-20.