Closing in on the Reservoir: Proactive Case Detection in High-Risk Groups
As a Strategy to Detect Plasmodium falciparum Asymptomatic Carriers in Cambodia
Abstract
In the frame of elimination strategies of Plasmodium falciparum (Pf), active case detection has been recommended as complementary approach to the existing passive case detection programs. We trialed a polymerase chain reaction (PCR)–based active detection strategy targeting asymptomatic individuals, named proactive case detection (PACD), with the aim of assessing its feasibility, the extra yield of Pf infections, and the at-risk population for Pf carriage status.
A pilot of PACD was conducted in 3 villages in Chey Saen district (Preah Vihear province, Cambodia), from December 2015 to March 2016. Voluntary screening and treatment, following health promotion sensitization, was used as mobilization strategy.
This research was supported by the UK Department for International Development’s Operational Research Capacity Building Programme led by the International Union Against TB and Lung Disease (The Union)
Citation
Rossi G, Vernaeve L, Van den Bergh R, Nguon C, Debackere M, Abello Peiri C, Van V, Khim N, Kim S, Eam R, Ken M, Khean C, De Smet M, Menard D, Kindermans J-M. Closing in on the Reservoir: Proactive Case Detection in High-Risk Groups as a Strategy to Detect Plasmodium falciparum Asymptomatic Carriers in Cambodia. Clinical Infectious Diseases. 2018