Capsular Polysaccharide Conjugate Vaccines against Contagious Bovine Pleuropneumonia: Immune Responses and Protection in Mice
Abstract
The immunogenicity of Mycoplasma mycoides subsp. mycoides small colony biotype (MmmSC) vaccines was investigated in BALB/c mice. Groups of mice were vaccinated with either (1) unconjugated capsular polysaccharide (CPS), (2) CPS covalently conjugated to ovalbumin via a carbodiimide reaction, (3) CPS non-covalently bound to latex microspheres, (4) CPS non-covalently complexed with rabbit anti-CPS IgG, and (5) whole inactivated, ultrasonically disrupted (WID) MmmSC. Only mice immunized with the CPS-ovalbumin conjugate exhibited a significant (P
Citation
Waite, E.R.; March, J.B. Capsular Polysaccharide Conjugate Vaccines against Contagious Bovine Pleuropneumonia: Immune Responses and Protection in Mice. Journal of Comparative Pathology (2002) 126 (2-3) 171-182. [DOI: 10.1053/jcpa.2001.0540]