A randomized trial to compare the safety, tolerability and effectiveness of three antimalarial regimens for the prevention of malaria in Nigerian patients with sickle-cell disease
Article in the Journal of Infectious Diseases
Abstract
Malaria prophylaxis is recommended for persons with sickle-cell disease but the value of this has been questioned. The aim of this study was to find out if intermittent preventive treatment with artesunate-mefloquine (ASMQ) fixed-dose combination treatment or sulfadoxine-pyrimethamine plus amodiaquine was more effective than daily proguanil for malaria prevention in subjects with sickle cell disease. Intermittent preventive treatment with ASMQ administered when sickle-cell disease patients come for routine clinic visits was well tolerated and more effective in preventing malaria than daily prophylaxis with proguanil.
Citation
Olaosebikan R, Ernest K, Bojang K, Mokuolu O, Rehman AM, Affara M, Nwakanma D, Kiechel JR, Ogunkunle T, Olagunju T, Murtala R, Omefe P, Lambe T, Bello S, Ibrahim O, Olorunsola B, Ojuawo A, Greenwood B, Milligan P. (2015) A randomized trial to compare the safety, tolerability and effectiveness of three antimalarial regimens for the prevention of malaria in Nigerian patients with sickle-cell disease. The Journal of Infectious Diseases, Volume 212, Issue 4, 15 August 2015, Pages 617–625, https://doi.org/10.1093/infdis/jiv093