Transparency data

Non-tech. summaries 2014: projects on multisystemic research

Projects granted during 2014 that have a primary purpose of basic research: multisystemic.


Non-technical summaries: projects granted in 2014, volume 16

This file may not be suitable for users of assistive technology. Request an accessible format.

If you use assistive technology (such as a screen reader) and need a version of this document in a more accessible format, please email Please tell us what format you need. It will help us if you say what assistive technology you use.


This document outlines the projects granted under the Animals (Scientific Procedures) Act 1986 during 2014 with a primary purpose of basic research: multisystemic.

The following projects were granted:

  • role of G protein-coupled receptors behaviour and homeostasis (G protein-coupled receptors, behaviour, homeostasis, vasopressin, apelin)

  • medical countermeasures to dangerous pathogens (medical countermeasures, infection, protection, defence)

  • generation and maintenance of transgenic mice (transgenics, microinjection, mice, genetics)

  • therapeutic target validation in fibrosis (fibrosis, signalling pathways, drug targets)

  • nutrition and lactation in ruminants (ruminant, nutrition, lactation, metabolism, rumen function)

  • breeding and typing of genetically altered mice (mouse, DNA binding proteins, signalling pathway, knockout, transgenic)

  • methods and tools for mouse genome engineering (mouse transgenesis method development refinement)

  • determining pathways that regulate lung inflammation (lung inflammation, injury, fibrosis)

  • electrical stimulation of muscle and research in alkaptonuria (muscle, activity, alkaptonuria)

  • centrosome biology in mammalian development, aging and stem cell function (development, stem cells, aging, cell division)

  • the mechanisms underlying mammalian obesity and type 2 diabetes (insulin resistance, diabetes, obesity, cognitive defects, metabolism)

  • neurobiology and inflammatory mechanisms (sensory nerves, cardiovascular, inflammation, neurobiology)

  • fumarate hydratase in cancer biology and metabolism (fumarate hydratase, cancer, metabolism, diabetes)

  • in vivo study of sound transmission to the third trimester fetus (fetus, ear, sound, in-utero, pregnancy)

  • studies to investigate laminitis predisposition (horse, laminitis, endothelium, insulin, metabolic)

  • the influence of barometric pressure changes upon membrane physiology and xenobiotic penetration (air pressure, penetration of drugs, skin, blood flow)

  • pre-clinical mouse models of human ciliopathies (embryogenesis, development, cilium, ciliopathies)

  • epigenetic reprogramming in mammalian development (epigenetics, methylation, germ cells, embryos, diet)

  • management of genetically altered rodent lines (genetic alteration embryo stem cell)

  • pathophysiological roles of podoplanin and its receptor CLEC-2 (podoplanin, CLEC -2, embryogenesis, vascular integrity)

Published 25 April 2016