A 1.5km section of road between the A509 Wilby Way Roundabout and the A5001 Skew Bridge Roundabout will shut at 8pm on Friday 17 October to 6am on Monday 20 October.
Traffic will be diverted via the A509 northbound and the A14 eastbound.
Highways Agency Project Manager Marcus Peart said:
The work will provide road users with a safer, smoother journey and also eliminate the need to keep coming back to carry out short-term patching repairs. However, to do that we need to close the carriageway completely for the safety of our workforce and the travelling public.
Closing the road over an entire weekend means we can do the work more efficiently and cause less disruption.
We advise people to allow extra time for their journeys and familiarise themselves with the diversion before setting off.
Members of the public should contact the Highways Agency Information Line on 0300 123 5000.
Journalists should contact the Highways Agency press office on 0844 693 1448 and use the menu to speak to the most appropriate press officer.