Thousands of visitors and locals are expected to attend the event which will take place in 3 stages between 1-3 May.
The race starts on Friday with a stage from Bridlington to Scarborough, followed by the second stage Selby to York and finishes on Sunday with a final stage from Wakefield to Leeds.
There are no planned closures on the Highways England network for the tour but plans are in place to manage traffic at key locations on the route.
Rolling road closures will take place along parts of the route and anyone travelling through the area is advised to allow extra time for their journey, or to plan an alternative route or time.
For more information and travel advice please visit the Tour De Yorkshire website.
Members of the public should contact the Highways England customer contact centre on 0300 123 5000.
Journalists should contact the Highways England press office on 0844 693 1448 and use the menu to speak to the most appropriate press officer.