The resurfacing work will be carried out on the northbound carriageway on the section between junctions 5 and 6 near Solihull, close to Birmingham Airport.
During the work, which will be carried out overnight between 9pm and 6am, the northbound exit slip road at junction 6 of the M42 will be closed.
The main carriageway of the northbound M42 will be reduced to one lane during the work between junctions 5 and 6, with a 50mph speed limit in force for safety reasons.
Northbound traffic looking to access Birmingham Airport at junction 6 of the M42 will be diverted off at junction 5 of the M42, and via the A41, Damson Parkway and the A45 onwards to the airport.
Traffic that misses junction 5 should proceed to junction 9 at Curdworth and turn around to head southbound back to junction 6 of the M42.
Highways Agency project sponsor Purnima Kaul said:
Motorists should expect some disruption during this overnight work and those travelling to the airport may need to allow extra time for their journeys in order to catch their flights.
The end result will be a smoother and much improved road surface, improving journeys for the travelling public.
Members of the public should contact the Highways Agency Information Line on 0300 123 5000.
Journalists should contact the Highways Agency press office on 0844 693 1448 and use the menu to speak to the most appropriate press officer.