Drivers are advised the closures will be in place between 8pm and 6am until 9 October. A temporary 50mph speed limit will be in place for the duration of the works.
Diversions will be clearly signposted. The A1 will be open at all other times.
Nick Adshead, Highways Agency project manager, said:
This resurfacing work has been planned overnight to minimise disruption and to take place when traffic flows are at their lowest. Drivers are asked to plan their journeys and to follow the signed diversions.
Members of the public should contact the Highways Agency Information Line on 0300 123 5000.
Journalists should contact the Highways Agency press office on 0844 693 1448 and use the menu to speak to the most appropriate press officer.