A closure of the B4073 underneath the bridge between Corncroft Lane and Birchall Lane will also be needed to ensure the safety of road users.
The work, which is part of a comprehensive package of bridge safety improvements and maintenance to benefit road users on the M5 near Gloucester, will take place between 8pm and 6am.
Clearly signed diversions will be in place for both closures.
Road users travelling north on the M5 will be advised to leave the motorway at junction 12, then follow the A38 and join the A417 westbound at Barnwood roundabout, at the C&G roundabout road users should take the first exit signposted for the A417, then at
Elmbridge Court roundabout take the fourth exit signposted A40 for Cheltenham and the M5, finally rejoining the M5 at junction 11.
Full details and regular updates on the works, including videos and photos, can be found on our dedicated M5 Gloucestershire Bridge Works Facebook page here.
Members of the public should contact the Highways Agency Information Line on 0300 123 5000.
Journalists should contact the Highways Agency press office on 0844 693 1448 and use the menu to speak to the most appropriate press officer.