Contractors for Highways England will be resurfacing the A66 between the A19 and Teesside Park starting on Sunday 24 July.
As part of the work, which will be carried out overnight between 9pm and 6am, the slip roads at the A19/A66 Stockton Road junction will be closed.
Highways England Project Manager Phil Leng said:
This project will provide drivers with safer and smoother journeys along this stretch of the A66 in Middlesbrough.
“Every effort is being made to ensure disruption to traffic is kept to a minimum. We are carrying out as much work as we can overnight while traffic levels are at their lowest.
Clearly signed diversions will be in place until the project is due to be completed on Friday 12 August.
Members of the public should contact the Highways England customer contact centre on 0300 123 5000.
Journalists should contact the Highways England press office on 0844 693 1448 and use the menu to speak to the most appropriate press officer.