Contractors for Highways England are resurfacing just under 2 miles of the A19 between Over Silton and Osmotherley.
The work, which is expected to be completed by the end of September, will be carried out overnight between 8pm and 6am.
Highways England Project Manager Phil Leng said:
This project will provide drivers with smoother and safer journeys along this stretch of the northbound A19 in Thirsk.
Every effort is being made to ensure disruption to traffic is kept to a minimum. We are carrying out as much work as we can overnight while traffic levels are at their lowest and we have scheduled our works to fit around the A1 Leeming to Barton scheme.
The work will be carried out from Sunday 18 September at 8pm until 6am on Thursday 22 September and will start again on Saturday 24 September at 8pm until 6am on Monday the 26 September.
Clearly signed diversions will be in place via the A19/A61 South Kilvington northbound exit slip road, the A168 to Northallerton, the A684 and back on at Osmotherley junction – northbound entry slip road.
Members of the public should contact the Highways England customer contact centre on 0300 123 5000.
Journalists should contact the Highways England press office on 0844 693 1448 and use the menu to speak to the most appropriate press officer.