Contractors for Highways England are resurfacing just over 3 miles of the A19 between Over Silton and Osmotherley.
The work, which is expected to be completed by Monday 5 September, will be carried out overnight between 8pm and 6am.
Highways England Project Manager Phil Leng said:
This project will provide drivers with safer journeys along this stretch of the northbound A19 in Thirsk.
Every effort is being made to ensure disruption to traffic is kept to a minimum. We are carrying out as much work as we can overnight while traffic levels are at their lowest.
We expect our contractors will have to return to the area at a later date but this will be scheduled in around closures on the A1 Leeming to Barton major project.
Clearly signed diversions will be in place via the A19/A61 South Kilvington northbound exit skip road, the A168 to Northallerton, the A684 and back on at Osmotherley junction – northbound entry slip road.
Members of the public should contact the Highways England customer contact centre on 0300 123 5000.
Journalists should contact the Highways England press office on 0844 693 1448 and use the menu to speak to the most appropriate press officer.