Contractors for Highways England are resurfacing the A19 northbound exit slip road for the A689 junction and making repairs to the road surface between the A1027 and the A689.
The work, which is expected to be completed by Friday 22 July, will be carried out overnight between 8pm and 6am.
Highways England Project Manager Phil Leng said:
This project will provide drivers with safer journeys along this stretch of the northbound A19 in Billingham.
Every effort is being made to ensure disruption to traffic is kept to a minimum. We are carrying out as much work as we can overnight while traffic levels are at their lowest.
Clearly signed diversions will be in place via the A1027, Wolviston Road and the A689 to rejoin at the A19/A689 junction.
Members of the public should contact the Highways England customer contact centre on 0300 123 5000.
Journalists should contact the Highways England press office on 0844 693 1448 and use the menu to speak to the most appropriate press officer.