Contractors for Highways England are resurfacing just over 1.5 miles of the A174 from the B1365 Blue Bell to the A172 Stokesley Road.
Work started on Tuesday 3 May and is being carried out overnight, weekdays between 8pm and 6am, but a full closure will be required from 8pm on Friday 20 May until 6am on Monday 23 May.
Highways England Project Manager Phil Leng said:
This project will provide drivers with safer and smoother journeys along this stretch of the eastbound A174 in Middlesbrough.
Every effort is being made to ensure disruption to traffic is kept to a minimum. We are carrying out as much work as we can overnight while traffic levels are at their lowest.
We need to close the A174 this weekend to allow deep level repairs to be made. These repairs would not be possible under overnight closures. We’d ask drivers to be aware when planning their journeys and thank them for their ongoing patience.
A clearly signed diversion route is in place via the B1365 Hemlington Lane, Stainton Way, and the A172 to rejoin the A174.
The project is expected to be completed by the end of the month, depending on the weather.
Work will then start on the westbound carriageway on Tuesday 31 May.
Contractors will be carrying out the work in two phases. Phase 1 includes overnight closures of the westbound carriageway between the A172 Stokesley Road and the B1380 Stainton for nearly 3miles.
Phase 2 will include overnight closures of the A174 between the B1365 Blue Bell and the A19 for nearly 2 miles.
Both phases of work will be carried out overnight between 8pm and 6am, with no closures on Friday or Saturday nights.
Clearly signed diversions will be in place.
Members of the public should contact the Highways England customer contact centre on 0300 123 5000.
Journalists should contact the Highways England press office on 0844 693 1448 and use the menu to speak to the most appropriate press officer.