The closures are necessary to enable new road construction work and the installation of deep drainage pipes and street lighting ducts.
The northbound carriageway will be closed from the exit slip road at the Newark A17/A46 junction to the Forest Road junction from Monday 6 October to Wednesday 8 October between 9pm and 5am.
The southbound carriageway of the A1 will be closed between 9pm and 5am from the exit slip road at Apleyhead to the entry slip road at Twyford Lane next Thursday and Friday 9-10 October.
Next Saturday 11 October lane 1 of the southbound carriageway will be closed between 8am and 7pm. A full closure will then be put in place overnight between 9pm and 5am.
A further southbound closure will then be in place on Friday 17 October between 10pm and 8am. On Saturday 18 October there will be a single lane closure on the southbound carriageway between 8am and 7 pm and a full closure between 7pm and 9am.
Graham Littlechild, project sponsor for the scheme, said:
This vital work will progress the scheme to the next stage, allowing construction of the bridge to the west of the A1, preparing the road for a drainage system for the central reservation, new street lighting and illuminated signs.
We urge road users to comply with the 40mph speed limit through the work area for their safety and to protect our workers. Please pay extra attention and follow the diversions during closures.
Once the scheme is completed motorists can expect improved journey times.
During the northbound closure traffic will be diverted via the A46, A616 and A614. There will also be local diversion routes between Newark & Elkesley. Elkesley village will be accessible via Twyford Lane and Twyford Bridge junction.
Traffic will be directed from Apleyhead to the A1/A46 junction at Newark via the A614, A616 and A46 during the southbound closure.
All diversions will be clearly signed in advance of closures.
Members of the public should contact the Highways Agency Information Line on 0300 123 5000.
Journalists should contact the Highways Agency press office on 0844 693 1448 and use the menu to speak to the most appropriate press officer.