There is no known interaction between oseltamivir and aspirin but aspirin must not be given to anyone younger than 16 year.
Article date: November 2009
We are updating the UK versions of the Patient Information Leaflet for oseltamivir (Tamiflu) to clarify the advice relating to aspirin use during treatment with Tamiflu. The Patient Information Leaflets, including those with the 30/45 mg paediatric formulations, stated that “Tamiflu can be taken with paracetamol, ibuprofen, or acetylsalicylic acid (aspirin)”. This reflects the fact that there is no known interaction between oseltamivir and aspirin. It must not be interpreted that aspirin can be given to anyone younger than 16 years with Tamiflu. The use of aspirin is, and remains, contraindicated under 16 years because of the risk of Reye’s syndrome.