Article date: August 2007
Dopamine agonists (eg, apomorphine [APO-go], bromocriptine [Parlodel], cabergoline [Cabaser, Dostinex], levodopa, pergolide [Celance], piribedil, pramipexole [Mirapexin], quinagolide [Norprolac], and ropinirole [Adartrel▼, Requip]) are used in the management of patients with Parkinson’s disease; other uses include restless legs syndrome and endocrine disorders.
Evidence from spontaneous adverse reaction reports and the literature, suggest that pathological gambling and increased libido, including hypersexuality, may be rare class effects of dopamine agonists.
Product information for medicines that contain dopamine agonists or levodopa, or both, is being updated to include the following wording:
Healthcare professionals are advised to warn patients about these possible side-effects, and to inform patients to seek help from their doctor if they, their family, or their carer notice that their behaviour is unusual.
Article citation: Drug Safety Update August 2007; Vol 1, Issue 1: 6