Clarification: ACE inhibitors and angiotensin II receptor antagonists

Use during breastfeeding

Article date: July 2009

We have received some feedback and queries about our drug safety advice article on the use of ACE inhibitors and angiotensin II receptor antagonists during breastfeeding, which was published in the May 2009 issue of the bulletin.

We would like to clarify that although ACE inhibitors and angiotensin II receptor antagonists are generally not recommended for use by breastfeeding mothers, they are not absolutely contraindicated. Healthcare professionals may prescribe these medicines during breastfeeding if they consider that this treatment is essential for the lactating mother. In particular, the original article advised that in mothers who are breastfeeding older infants, the use of captopril, enalapril, or quinapril may be considered if an ACE inhibitor is necessary for the mother. Careful follow-up of the infant for possible signs of hypotension is recommended.

Article citation: Drug Safety Update July 2009, vol 2 issue 12: 10a.

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