Willingness to participate in preventive HIV vaccine trials in a community-based cohort in south western Uganda
Objectives. To assess willingness to participate in HIV vaccine trials and possible barriers to participation.
Methods. Questionnaire survey of participants completing a 2-year community-based HIV Vaccine Preparedness Study, followed by cross sectional analysis of data.
Results. 95% of participants were willing to participate in a trial with similar attributes to the Vaccine Preparedness Study. Certain hypothetical trial attributes significantly reduced willingness to participate: The requirement to delay pregnancy (for females) had the largest effect, reducing willingness to participate from 97% to 23% (P
Conclusions. We found a high level of willingness to participate in HIV vaccine trials in this population. However, certain HIV vaccine trial requirements were associated with reduced willingness to participate. Community as well as individual concerns will have to be carefully addressed in planned HIV vaccine trials
Tropical Medicine and International Health (2009) 14 (2) 196-203 [DOI: 10.1111/j.1365-3156.2008.02200.x]