H9N2 avian influenza viruses are primarily a disease of poultry; however, they occasionally infect humans and are considered a potential pandemic threat. Little work has been performed to assess the intrinsic biochemical properties related to zoonotic potential of H9N2 viruses. The objective of this study, therefore, was to investigate H9N2 haemagglutinins (HAs) using 2 well-known correlates for human adaption: receptor-binding avidity and pH of fusion
This work arises from the Zoonoses and Emerging Livestock Systems (ZELS) programme.
Peacock T, Benton D, Sadeyen J, Chang P, Sealy J, Bryant J, Martin S, Shelton H, McCauley J, Barclay W, Iqbal M (2017). Variability in H9N2 haemagglutinin receptor-binding preference and the pH of fusion. Emerging Microbes Infection. 6(3): e11
Variability in H9N2 haemagglutinin receptor-binding preference and the pH of fusion