This article reviews the various vaginal microbicides currently being tested for use to prevent transmission of HIV and other sexually transmitted infections. It outlines their different mechanisms of action (non-specific antimicrobials, attachment/fusion/entry inhibitors, and intracellular replication inhibitors), potential usefulness and safety profile. Formulations and the problems of evaluating effectiveness are also discussed.
Cates, W.; Rosenberg, Z. Vaginal microbicides - what does the future hold? Contemporary Ob Gyn (2008) : [Supplement]