The objective of this review was to assess the effects of vaccines to prevent plague.
Study selection criteria: Randomised trials comparing live and killed plague vaccines against no intervention, placebo, other plague vaccines or vaccines against other disease (control vaccines).
Data collection and analysis: Three reviewers assessed the eligibility of trials.
Main results: No trials were included.
Conclusions: There is not enough evidence to evaluate the effectiveness of any plague vaccine, or the relative effectiveness between vaccines and their tolerability. Circumstantial data from observational studies suggest that killed types may be more effective and have fewer adverse effects than attenuated types of vaccine. No evidence appears to exist on the long-term effects of any plague vaccine.
Jefferson, T.; Demicheli, V.; Pratt, M. Vaccines for preventing plague. Cochrane Database of Systematic Reviews (1998) Issue 1, Art. No.: CD000976. [DOI: 10.1002/14651858.CD000976]