Understanding the challenges of AIDS vaccine development - April 2007. What are the major scientific obstacles to the development of an effective AIDS vaccine?

Abstract

The following obstacles to an AIDS vaccine are discussed: the genetic diversity of HIV; the relative unimportance of antibodies in controlling the disease naturally; the fact that it is the immune system that is attacked in AIDS; the lack of good animal models of the disease; and difficulties in developing the right antigens for a vaccine.

Citation

Vax Online Primer

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