Antibiotics target functions that are required for bacterial growth and
survival. As genetic tools for studying Mycobacterium tuberculosis
continue to improve we are increasingly able to identify genes that
encode these important effectors. Here we review the strategies that
have been used to identify and validate essential genes in mycobacteria
and look forward to possible future advances.
This is one of a series of articles commissioned and edited by the TB
Alliance and published in a special issue of Tuberculosis, entitled
'Key issues in TB drug research and development'.
Tuberculosis (2008) 88, Supplement 1, S19-S24 [doi:10.1016/S1472-9792(08)70033-7]
The many roads to essential genes.