The importance of recent infection with Mycobacterium tuberculosis in an area with high HIV prevalence: a long-term molecular epidemiological study in Northern Malawi.

From:
Department for International Development
Published
1 January 2005
Country:
Malawi
Document Type:
Journal Article
Theme:
Health
Authors:
Glynn, J.R., Yates, M.D., Drobniewski, F., Crampin, A.C., Fine, P.E., Traore, H., Mwaungulu, F.D., Ngwira, B.M., Ndlovu, R.

Abstract

BACKGROUND: The proportion of cases of tuberculosis due to recent infection can be estimated in long-term population-based studies using molecular techniques. Here, we present what is, to our knowledge, the first such study in an area with high human immunodeficiency virus (HIV) prevalence. METHODS: All patients with tuberculosis in Karonga District, Malawi, were interviewed. Isolates were genotyped using restriction-fragment-length polymorphism (RFLP) patterns. Strains were considered to be \"clustered\" if at least 1 other patient had an isolate with an identical pattern. RESULTS: RFLP results were available from 83% of culture-positive patients from late 1995 to early 2003. When strains with

Citation

Journal of Infectious Diseases (2005) 192 (3) pp. 480-487 [DOI: 10.1086/431517].

Published 1 January 2005
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