The fourth national anti-tuberculosis drug resistance survey in Vietnam
To determine the prevalence of resistance to the 4 main first-line anti-tuberculosis drugs in Vietnam
Abstract
Setting
Vietnam’s Fourth National Anti-Tuberculosis Drug Resistance Survey was conducted in 2011.
Objective
To determine the prevalence of resistance to the four main first-line anti-tuberculosis drugs in Vietnam.
Methods
80 clusters were selected using a probability proportion to size approach. Drug susceptibility testing (DST) against the four main first-line anti-tuberculosis drugs was performed.
Results
A total of 1629 smear-positive tuberculosis (TB) patients were eligible for culture. Of these, DST results were available for 1312 patients, including 1105 new TB cases, 195 previously treated TB cases and 12 cases with an unknown treatment history. The proportion of cases with resistance to any drug was 32.7% (95%CI 29.1–36.5) among new cases and 54.2% (95%CI 44.3–63.7) among previously treated cases. The proportion of multidrug-resistant TB (MDR-TB) cases was 4.0% (95%CI 2.5–5.4) in new cases and 23.3 (95%CI 16.7–29.9) in previously treated cases.
Conclusions
The fourth drug resistance survey in Viet Nam found that the proportion of MDR-TB among new and previously treated cases was not significantly different from that in the 2005 survey. The National TB Programme should prioritise the detection and treatment of MDR-TB to reduce transmission of MDR-TB in the community.
This research was supported by the UK Department for International Development’s Operational Research Capacity Building Programme led by the International Union Against TB and Lung Disease (The Union)
Citation
Nhung NV, Hoa NB, Sy DN, Hennig CM, Dean AS (2015) The fourth national anti-tuberculosis drug resistance survey in Vietnam. International Journal for Tuberculosis and Lung Disease 2015 Jun;19(6):670-5. doi: 10.5588/ijtld.14.0785.
Links
The fourth national anti-tuberculosis drug resistance survey in Vietnam