Structure–Activity Relationship Studies of Orally Active Antimalarial 3,5-Substituted 2-Aminopyridines
- Department for International Development
- 1 January 2012
- Document Type:
- Journal Article
- Waterson, D., Charman, S.A., White, K.L., Wittlin, S., Scheurer, C. Chibale, K., Douelle, F., Nchinda, A.T., Ryan, E., Witty, M.J., Younis, Y., Bashyam, S., Joseph, J.T., Katneni, K., Le Manach, C., Cabrera, D.G., Feng TzuShean, Kamber, J., Montagnat, O.D., Street, L.J., and Zabiulla, K.M.
In an effort to address potential cardiotoxicity liabilities identified with earlier frontrunner compounds, a number of new 3,5-diaryl-2-aminopyridine derivatives were synthesized. Several compounds exhibited potent antiplasmodial activity against both the multidrug resistant (K1) and sensitive (NF54) strains in the low nanomolar range. Some compounds displayed a significant reduction in potency in the hERG channel inhibition assay compared to previously reported frontrunner analogues. Several of these new analogues demonstrated promising in vivo efficacy in the Plasmodium berghei mouse model and will be further evaluated as potential clinical candidates. The SAR for in vitro antiplasmodial and hERG activity was delineated.
Cabrera, D.G.; Douelle, F.; Younis, Y.; Feng TzuShean; Le Manach, C.; Nchinda, A.T.; Street, L.J.; Scheurer, C.; Kamber, J.; White, K.L.; Montagnat, O.D.; Ryan, E.; Katneni, K.; Zabiulla, K.M.; Joseph, J.T.; Bashyam, S.; Waterson, D.; Witty, M.J.; Charman, S.A.; Wittlin, S.; Chibale, K. Structure&#8211;Activity Relationship Studies of Orally Active Antimalarial 3,5-Substituted 2-Aminopyridines. Journal of Medicinal Chemistry (2012) 55 (24) 11022-11030. [DOI: 10.1021/jm301476b]
Published: 1 January 2012
Document Type: Journal Article
Authors: Waterson, D. Charman, S.A. White, K.L. Wittlin, S. Scheurer, C. Chibale, K. Douelle, F. Nchinda, A.T. Ryan, E. Witty, M.J. Younis, Y. Bashyam, S. Joseph, J.T. Katneni, K. Le Manach, C. Cabrera, D.G. Feng TzuShean Kamber, J. Montagnat, O.D. Street, L.J. Zabiulla, K.M.