The Revised National Tuberculosis Control Program (RNTCP) of India
recommends follow-up sputum smear examination at two months into the
continuation phase of treatment. The main intent of this (mid-CP)
follow-up is to detect patients not responding to treatment around
two-three months earlier than at the end of the treatment. However, the
utility of mid-CP follow-up under programmatic conditions has been
questioned. The authors undertook a multi-district study to determine if
mid-CP follow-up is able to detect cases of treatment failures early
among all types of patients with sputum smear-positive TB.
They reviewed existing records of patients with sputum smear-positive TB
registered under the RNTCP in 43 districts across three states of India
during a three month period in 2009. They estimated proportions of
patients that could be detected as a case of treatment failure early,
and assessed the impact of various policy options on laboratory workload
and number needed to test to detect one case of treatment failure early.
Gandhi, MP.; Kumar, AM.; Toshniwal, MN.; Reddy, RH.; Oeltmann, JE.; Nair, SA.; Satyanarayana, S.; Dewan, PK.; Mannan, S. Sputum Smear Microscopy at Two Months into Continuation-Phase: Should It Be Done in All Patients with Sputum Smear-Positive Tuberculosis? PLoS ONE (2012) 7 (6) e39296. [DOI: 10.1371/journal.pone.0039296]
Sputum Smear Microscopy at Two Months into Continuation-Phase: Should It Be Done in All Patients with Sputum Smear-Positive Tuberculosis?