Young children and pregnant women are particularly vulnerable to severe malaria. Those suffering are frequently on the brink of coma and multi-organ failure by the time they arrive at a clinic .Intravenous quinine has been used to treat severe malaria for decades; however, the margin between efficacious doses and toxic doses is narrow, making its administration complex, lengthy and risky. Injectable artesunate is better tolerated, easier to use and saves more lives than quinine. It is the fastest acting antimalarial agent available.
MMV. Severe malaria: saving more lives with injectable artesunate. (2013) 2 pp.