Screening and hit evaluation of a chemical library against blood-stage Plasmodium falciparum

A chemical library of 250,000 compounds, evaluated in a blood-stage Plasmodium falciparum growth inhibition assay

Abstract

In view of the need to continuously feed the pipeline with new anti-malarial agents adapted to differentiated and more stringent target product profiles (e.g. new modes of action, transmission-blocking activity or long-duration chemo-protection), a chemical library consisting of more than 250,000 compounds has been evaluated in a blood-stage Plasmodium falciparum growth inhibition assay and further assessed for chemical diversity and novelty.

Citation

Avery, V.M.; Bashyam, S.; Burrows, J.N.; Duffy, S.; Papadatos, G.; Puthukkuti, S.; Sambandan, Y.; Singh, S.; Spangenberg, T.; Waterson, D.; Willis, P. Screening and hit evaluation of a chemical library against blood-stage Plasmodium falciparum. Malaria Journal (2014) 13 (1) 190. [DOI: 10.1186/1475-2875-13-190]

Screening and hit evaluation of a chemical library against blood-stage Plasmodium falciparum

Published 1 January 2014