Safety of a trivalent meningococcal ACW135 vaccine among young children in Ethiopia

From:
Department for International Development
Published
1 January 2007
Country:
Ethiopia
Document Type:
Journal Article
Theme:
Health
Authors:
Chandramohan, D., Nelson, C.B., Aseffa, A., Bedru, A., Yamuah, L., Arga, D., Worku, A., Engers, H.D.

Abstract

A phase II open and parallel reactogenicity, immunogenicity and safety trivalent meningitis vaccine (Mencevax) trial was conducted on 413 volunteer 2–29-year-old rural residents in Ethiopia in November/December 2005. Adverse events (AE) were monitored at 1 h, 1, 2, 3, 7 and 28 days after vaccination. No serious AE occurred except for burn injury (one) and severe malaria (one) after day 28. Irritability (45/411), loss of appetite (27/411), pain at injection site (26/412), dizziness (18/409), crying (14/411), insomnia, headache and diarrhoea (13/411) were the most frequent AEs. Overall, the vaccine is safe in the age groups studied.

Citation

Vaccine (2007) 25 (Supplement 1) A79-A82 [doi:10.1016/j.vaccine.2007.04.046]

Safety of a trivalent meningococcal ACW135 vaccine among young children in Ethiopia

Published 1 January 2007
Contents