The purpose of this paper is not to present the approaches adopted by RIU projects as a blueprint for enhancing the contribution of agricultural research to development. The paper begins with a brief overview of the past and contemporary debates on enhancing the contribution of agricultural research for innovation. A brief outline of the RIU programme in South Asia is first discussed. This is followed by a description of select cases from RIU’s South Asia portfolio. Finally, the key features of these cases with implications for enhancing agricultural innovation are discussed.