The authors selected 80 clusters of TB cases were selected using a probability-proportion-to-size approach. To identify MDR-TB cases, drug susceptibility testing (DST) was performed for the four major first-line TB drugs. DST of second-line drugs (ofloxacin, amikacin, kanamycin, capreomycin) was performed on isolates from MDR-TB cases to identify pre-XDR and XDR cases.
The authors conclude that the survey provides the first estimates of the proportion of XDR-TB among MDR-TB cases in Viet Nam and provides important information for local policies regarding second-line DST. Local policies and programmes that are geared towards TB prevention, early diagnosis and treatment with effective regimens are of high importance.
This research was supported by the UK Department for International Development’s Operational Research
Capacity Building Programme led by the International Union Against TB and Lung Disease (The Union)
Hoa Binh Nguyen, Nhung Viet Nguyen, Huong Thi Giang Tran, Hai Viet Nguyen, Quyen Thi Tu Buif (2016) WPSAR Vol 7, No 2, 2016 | doi: 10.5365/wpsar.2016.7.2.002
Prevalence of resistance to second-line tuberculosis drugs among multidrug-resistant tuberculosis patients in Vietnam, 2011