Pregnancy and pregnancy outcome among women in the DART trial.
Among 1866 women of childbearing age enrolled in the DART trial of antiretroviral therapy monitoring strategies in Uganda and Zimbabwe, 221 pregnancies were reported (in 198 women) after a median of 2.8 years of follow-up. Almost all women continued taking their drugs during pregnancy and delivery. Pregnancy rates increased over time; rates of foetal loss varied between sites. Among the 164 pregnancies which had reached a known outcome at the time of writing, 55% resulted in a live birth. Congenital abnormality rates appeared similar to those in other studies. No infant had been diagnosed as infected at the time of writing, although some women chose to breastfeed; follow-up of infants was ongoing.
14th Conference on Retroviruses and Opportunistic Infections, Los Angeles, USA, 25-28 February 2007: Abstract 746.