Predictors and timing of ATT initiation among HIV-TB patients at ART centres of Karnataka, India: two year follow-up
Patients registered at 16 ART centres formed the study cohort in 2009 and were followed till 2011
Abstract
Background
In India, TB and HIV co-infection remains as a serious public health problem. From 2006 onwards, the intensified TB-HIV collaborative activities are being jointly implemented by National AIDS Control Programme (NACP) and Revised National TB Control programme (RNTCP) at high HIV burden states.
Objectives
To determine (a) the predictors of outcome among a cohort of HIV-TB co-infected patients after 2 years after initiation of ART treatment. (b) prognostic significance of time difference between the initiation of ATT and ART in HIV-TB co-infected patients.
Methods
Patients registered at 16 ART centres in Karnataka, from October through December 2009 formed the study cohort and were followed till December 2011.
Results
A total of 604 HIV-TB patients were registered. Follow-up (a) at the end of one year had shown 63.6% (377)patients with unfavorable TB treatment outcomes (b) at the end of second year, 55.6% (336)patients were alive on ART treatment. The variables male, smear negative TB, CD4 count less than 50cells per cumm and unfavorable TB outcome were significantly associated with unfavorable ART treatment outcome.
Conclusions
The programmes need to review the existing strategies and strengthen HIV-TB collaborative activities for timely treatment initiation with intensive monitoring of HIV-TB patients on treatment.
This research was supported by the UK Department for International Development’s Operational Research Capacity Building Programme led by the International Union Against TB and Lung Disease (The Union)
Citation
Shastri S, Nagaraja SB, Tripathy JP, Satyanarayana S, Rewari BB (2015) Predictors and Timing of ATT Initiation among HIV-TB Patients at ART Centers of Karnataka, India: Two Year FollowUp. PLoS ONE 10(9): doi:10.1371/journal.pone.0138603