Spray drying represents an elegant one-step process for generating powder products with unique particle characteristics. Respiratory delivery of powder vaccines for the prevention of infectious diseases has shown great promise. Pulmonary delivery using powder vaccine aerosols is an approach to immunization that offers advantages over the use of injection in terms of both delivery technology and vaccine formulation. Powder vaccines for needle-free delivery have been successfully produced during the past decade. The essential elements for the preparation of a powder vaccine through spray drying are reviewed in this chapter. For example, the screening of formulations, the spray dryers from laboratory scale to aseptic manufacturing facilities, and the selection of dry powder inhalers (DPIs) for pulmonary delivery. The advantages and challenges of manufacturing powder vaccines are also discussed.
Jin, T.; Tsao, E. Powder Vaccines for Pulmonary Delivery. Immunomics Reviews (2013) 5: 291-301. [DOI: 10.1007/978-1-4614-5070-2_14]