Pharmacokinetics of lamivudine, abacavir and zidovudine administered twice-daily as syrups versus scored tablets in HIV-1 infected Ugandan children.

Abstract

Replacing syrups by tablets as the formulation of antiretroviral drugs in HIV-1-infected Ugandan children made no significant difference to the pharmacokinetics of zidovudine or abacavir (after allowing for the larger dose contained in the tablets), but dose-normalised lamivudine exposure was about 55% higher with tablets than with syrup.

Citation

Kasirye, P.; Kendall, L.; Musiime, V.; Adkison, K.; Kekitiinwa, A.; Ferrier, A.; Opilo, W.; Lou, Y.; Bwakura-Dangarembizi, M.F.; Nahirya-Ntege, P.; Bakeera-Kitaka, S.; Ssenyonga, M.; Snowden, W; Burger, D.; Walker, A.S.; Gibb, D.M. Pharmacokinetics of lamivudine, abacavir and zidovudine administered twice-daily as syrups versus scored tablets in HIV-1 infected Ugandan children. Presented at Tenth International Congress on Drug Therapy in HIV Infection, Glasgow, UK, 7-11 November 2010. (2010)

Pharmacokinetics of lamivudine, abacavir and zidovudine administered twice-daily as syrups versus scored tablets in HIV-1 infected Ugandan children.

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