Malaria rapid diagnostic tests (RDTs) are appropriate for case management, but persistent antigenaemia is a concern for HRP2-detecting RDTs in endemic areas. It has been suggested that pan-pLDH test bands on combination RDTs could be used to distinguish persistent antigenaemia from active Plasmodium falciparum infection, however this assumes all active infections produce positive results on both bands of RDTs, an assertion that has not been demonstrated.
Gatton, M.L.; Rees-Channer, R.R.; Glenn, J.; Barnwell, J.W.; Qin Cheng; Chiodini, P.L.; Incardona, S.; Gonzalez, I.J.; Cunningham, J. Pan-Plasmodium band sensitivity for Plasmodium falciparum detection in combination malaria rapid diagnostic tests and implications for clinical management. Malaria Journal (2015) 14 (1) 115. [DOI: 10.1186/s12936-015-0629-z]