Novel Compounds for the Treatment of Chagas Disease

Abstract

Several series of compounds (including natural products and agrochemicals) with activity against Trypanosoma cruzi were evaluated. A new lead series has been developed based on the herbicide Fenarimol; they are potent, selective, non-cytotoxicity and easy to synthesise. Lead compound BS207 has good oral bioavailability and is active in a mouse model of T. cruzi infection.

Citation

Presentation from American Society of Tropical Medicine and Hygiene 58th Annual Meeting, Washington, DC, USA, 18-22 November 2009.

Novel Compounds for the Treatment of Chagas Disease

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