Chagas disease is one of the most neglected of the tropical diseases, yet millions of people are infected with it. There are only two available drugs to treat it, both of which are more than 40 years old and neither of which is ideal. As the global population has become more internationally mobile, Chagas disease has spread from Latin America to become a worldwide threat. This Outlook highlights some of the progress in understanding and treating Chagas disease over its 101 years of recent history and outlines the challenges still to be met.
Chagas disease. Nature (2010) 465 (n7301_supp) S3-S3. [DOI: 10.1038/465S3a]