Clinical trials are an essential source of scientific evidence on the safety and effectiveness of health interventions. Prospectively registering information about a trial before enrolling participants, tracking changes to that information via a publicly accessible audit trail, and reporting results on completion of the trial helps protect against reporting biases and over-optimistic conclusions about treatment benefits.
Grobler, L.; Siegfried, N.; Askie, L.; Hooft, L.; Tharyan, P.; Antes, G. National and multinational prospective trial registers. Lancet (2008) 372 (9645) 1201-1202. [DOI: 10.1016/S0140-6736(08)61498-1]