Modeling the Control of Trypanosomiasis Using Trypanocides or Insecticide-Treated Livestock

Abstract

Background: In Uganda, Rhodesian sleeping sickness, caused by Trypanosoma brucei rhodesiense, and animal trypanosomiasis caused by T. vivax and T. congolense, are being controlled by treating cattle with trypanocides and/or insecticides. We used a mathematical model to identify treatment coverages required to break transmission when host populations consisted of various proportions of wild and domestic mammals, and reptiles.

Methodology/Principal Findings: An Ro model for trypanosomiasis was generalized to allow tsetse to feed off multiple host species. Assuming populations of cattle and humans only, pre-intervention Ro values for T. vivax, T. congolense, and T. brucei were 388, 64 and 3, respectively. Treating cattle with trypanocides reduced R0 for T. brucei to 65% of cattle were treated, vs 100% coverage necessary for T. vivax and T. congolense. The presence of wild mammalian hosts increased the coverage required and made control of T. vivax and T. congolense impossible. When tsetse fed only on cattle or humans, R0 for T. brucei was
Conclusions/Significance: In settled areas of Uganda with few wild hosts, control of Rhodesian sleeping sickness is likely to be much more effectively controlled by treating cattle with insecticide than with trypanocides.

Citation

Hargrove, J.W.; Ouifki, R.; Kajunguri, D.; Vale, G.A.; Torr, S.J. Modeling the Control of Trypanosomiasis Using Trypanocides or Insecticide-Treated Livestock. PLoS Neglected Tropical Diseases (2012) 6 (5) e1615. [DOI: 10.1371/journal.pntd.0001615]

Modeling the Control of Trypanosomiasis Using Trypanocides or Insecticide-Treated Livestock

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