Meningococcal group C and w135 immunological hyporesponsiveness in African toddlers

Abstract

A phase II clinical study was conducted in African toddlers (aged 12 to 23 months), with subjects receiving either investigational meningococcal group A conjugate (PsA-TT), meningococcal ACWY polysaccharide (PsACWY), or Haemophilus influenzae type b (Hib-TT) vaccine. Ten months following vaccination, the 3 study groups were further randomized to receive a dose of PsA-TT, a 1/5 dose of PsACWY, or a dose of Hib-TT vaccine. Group A serum bactericidal antibody (SBA) results have been reported previously, with PsA-TT demonstrating superior immunogenicity versus PsACWY vaccine. Immunogenicity for serogroups W135 and C was assessed by SBA assay to investigate the impact of multiple doses in this age group. Blood samples were taken prior to vaccination, 28 days and 40 weeks post-primary vaccination, and 7 and 28 days post-booster vaccination with a 1/5 dose of PsACWY. Subjects who had previously received a full dose of PsACWY had W135 SBA geometric mean titers (GMTs) of 26.1 and 4.4 at 7 and 28 days post-booster vaccination with a 1/5 PsACWY dose, respectively, whereas the W135 SBA GMTs of naïve subjects at these time points following vaccination with a 1/5 dose of PsACWY were 861.1 and 14.6, respectively. Similar differences were observed for serogroup C, with SBA GMTs of 99 and 5.9 at 7 and 28 days post-booster vaccination with a 1/5 dose of PsACWY, respectively, for naïve subjects, compared to 4.1 and 3.2 for previously vaccinated subjects. Immunologic hyporesponsiveness for groups C and W135 was observed following a full dose of PsACWY vaccine at 12 to 23 months of age and a 1/5 dose of PsACWY 10 months later compared to the case for PsACWY-naïve subjects receiving a 1/5 dose of PsACWY vaccine.

Citation

Findlow, H.; Sow, S.; Borrow, R.; Tapia, M.; Haidara, F.C.; Akinsola, A.K.; Idoko, O.T.; Diallo, F.; Adegbola, R.; Tang YuXiao; Parulekar, V.; Chadha, H.; Mabey, L.; Holme, D.; Townsend, K.; Chaumont, J.; LaForce, F.M.; Kilkarni, P.S.; Marchetti, E.; Viviani, S.; Hassan-King, M.; Preziosi, M.P. Meningococcal Group C and W135 Immunological Hyporesponsiveness in African Toddlers. Clinical and Vaccine Immunology (2011) 18 (9) 1492-1496. [DOI: 10.1128/CVI.05020-11]

Meningococcal group C and w135 immunological hyporesponsiveness in African toddlers

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