Mannitol and other osmotic diuretics as adjuncts for treating cerebral malaria.

From:
Department for International Development
Published
1 January 2004
Document Type:
Literature Review
Theme:
Health
Authors:
Afolabi, B.B., Okoromah, C.A.N.

Abstract

Background: The main treatment for cerebral malaria is parenteral antimalarials. Mannitol and urea are used as adjunct therapy for cerebral malaria, but the World Health Organization does not recommend them. Objectives: To compare mannitol or urea to placebo or no treatment for treating children and adults with cerebral malaria. Selection criteria: Randomized and quasi-randomized controlled trials comparing mannitol or urea to placebo or no treatment in children and adults with cerebral malaria. Data collection and analysis: No trials met the inclusion criteria. Main results: No trials met the inclusion criteria. Conclusions: No randomized or quasi-randomized controlled trials to support or refute the use of mannitol or urea as adjuncts for treating cerebral malaria in clinical practice were identified. This is likely to require a multicentre trial.

Citation

The Cochrane Database of Systematic Reviews 2004, Issue 4. Art. No.: CD004615. DOI: 10.1002/14651858.CD004615.pub2.

Mannitol and other osmotic diuretics as adjuncts for treating cerebral malaria.

Published 1 January 2004
Contents